Request for Applications: Two Patient-Partnered RFAs with Rare Disease Focus
Applications due May 24, 2022 by 5 p.m. Pacific Time
The Chan Zuckerberg Initiative (CZI) invites applications from collaborative teams bringing together patient-led rare disease organizations and research teams for 4-year research projects aimed at advancing our understanding of the fundamental science of rare diseases across two RFAs:
- The Patient-Partnered Collaborations for Single-Cell Analysis of Rare Inflammatory Pediatric Disease RFA aims to support the application of single-cell biology methods to rare inflammatory pediatric diseases in order to clarify cellular mechanisms of disease, improve understanding of disease heterogeneity, identify biomarkers, and improve diagnosis.
The overarching goal is to support interdisciplinary teams as they characterize the cellular mechanisms underlying rare inflammatory diseases, including possible identification of biomarkers and elucidation of disease pathways that will clarify disease stratification or identify therapeutic opportunities. Patient organizations are expected to be active collaborators on this research opportunity and full partners in the development of the grant application to directly inform research questions that will have the greatest impact on rare disease patients, and to engage in study design, patient engagement, and research dissemination. Learn more and apply now.
- The Patient-Partnered Collaborations for Rare Neurodegenerative Disease RFA aims to advance the understanding of the pathophysiology and mechanistic underpinnings of rare neurodegenerative and neurological disorders.
CZI’s Neurodegeneration Challenge Network model is built on the vision that progress in solving neurodegenerative diseases will come from bringing new people into the neurodegeneration field from diverse disciplines and expertise; building interdisciplinary collaborations; empowering the broader scientific community with robust tools and platforms, and creating a culture of open science. The Patient-Partnered Collaborations for Rare Neurodegenerative Disease RFA extends on this vision by expanding the scope of diseases and biological problems covered within NDCN, and widens the circle of experts and stakeholders to include patient organizations as collaborators, building on learnings from CZI’s Rare as One Network and CZI’s efforts in patient-directed research. Learn more and apply now.
For more information about the Patient-Partnered Collaborations RFAs, potential applicants are encouraged to attend an informational webinar on Wednesday, February 16 from 9 – 10:30 a.m. Learn more and register.
Applications will be accepted until 5 p.m. Pacific Time on May 24, 2022.
Questions? Email sciencegrants@chanzuckerberg.